Bases de datos bibliográficas

COVID-19 SARS-COV-2 preprints from BioRxiv MedRxiv

• SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm 6 diciembre, 2024
  Like all viruses, SARS-CoV-2, the causative agent of COVID-19, relies on host cell resources to replicate. Our study reveals that, among these resources, SARS-CoV-2 hijacks the oxysterol-binding protein 1 (OSBP1) transporter to exploit the Golgi-bound phosphatidylinositol-4-phosphate (PI4P) pool. This leads to a depletion of Golgi-resident PI4P, triggering the activation of the ATM DNA Damage Response […]
  Rebendenne, A.
• Exploring clinical characteristics of COVID-19 in children and adolescents using a machine-learning approach 6 diciembre, 2024
  Introduction: The epidemiology and clinical characteristics of COVID-19 evolved due to new SARS-CoV-2 variants of concern (VOCs). The Omicron VOC's higher transmissibility increased pediatric COVID-19 cases and hospital admissions. Most research during the Omicron period has focused on hospitalized cases, leaving a gap in understanding the disease's evolution in community settings. This study targets children […]
  Fiandrino, S.
• Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2 5 diciembre, 2024
  SARS-CoV-2 has largely evolved to resist antibody pressure, with each successive viral variant becoming more and more resistant to serum antibodies in the population. This evolution has rendered inactive all therapeutic monoclonal antibodies previously authorized, and it is now threatening the remaining clinical product for immunoprophylaxis against COVID-19. We report herein the isolation of a […]
  Wang, Q.
• Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus 5 diciembre, 2024
  SARS-CoV-2 infection poses a major threat to public health, and understanding the mechanism of viral replication and virion release would help identify therapeutic targets and effective drugs for combating the virus. Herein, we identified E3 ubiquitin-protein ligase Itchy homolog (ITCH) as a central regulator of SARS-CoV-2 at multiple steps and processes. ITCH enhances the ubiquitination […]
  Xiang, Q.
• Optimal intervention strategies for a new pandemic: The case of Covid-19 5 diciembre, 2024
  We present an age-stratified SEIR-type model of the Norwegian population, which is extended to include the effects of broad types of Non-Pharmaceutical Interventions (NPIs) like general lockdown-policies, contact tracing and quarantine and border control. The model can be used to explore the spread of a new virus with given virulence and transmissibility, and to assess […]
  Holden, S.
• Intra-familial dynamics of mental distress during the Covid-19 lockdown 5 diciembre, 2024
  ImportanceLockdowns and social restrictions imposed in response to the Covid-19 pandemic intensified the proximity and reciprocal exposure among members of nuclear families. It is unclear how variation in mental distress during this period is attributed to family members influence. ObjectiveUsing genetic data from family members, it is possible to disentangle parent-driven, child-driven, and partner-driven influences […]
  Pettersen, J. H.
• Genome-wide Machine Learning Analysis of Anosmia and Ageusia with COVID-19 5 diciembre, 2024
  The COVID-19 pandemic has caused substantial worldwide disruptions in health, economy, and society, manifesting symptoms such as loss of smell (anosmia) and loss of taste (ageusia), that can result in prolonged sensory impairment. Establishing the host genetic etiology of anosmia and ageusia in COVID-19 will aid in the overall understanding of the sensorineural aspect of […]
  Pietan, L.